The environmental stress response causes ribosome loss in aneuploid yeast cells
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چکیده
منابع مشابه
2 The environmental stress response: a common yeast response to diverse environmental stresses
Unicellular organisms require specific internal conditions for optimal growth and function, however sudden changes in the external environment can perturb the internal milieu, disrupting normal processes. Therefore, cells must maintain their internal system despite fluctuations in the external surroundings. One mechanism that yeast cells use to protect the internal system from the effects of en...
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Gains or losses of entire chromosomes lead to aneuploidy, a condition tolerated poorly in all eukaryotes analyzed to date. How aneuploidy affects organismal and cellular physiology is poorly understood. We found that aneuploid budding yeast cells are under proteotoxic stress. Aneuploid strains are prone to aggregation of endogenous proteins as well as of ectopically expressed hard-to-fold prote...
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Exponential phase cells of the yeast, Saccharomyces cerevisiae when treated with a non-lethal concentration of hydrogen peroxide (H2O2; 0.2mM) for 60 min adapted to become resistant to the lethal effects of a higher dose of H2O2 (2mM). From studies using cycloheximide to inhibit protein synthesis it appears that protein synthesis is required for maximal induction of resistance but that some deg...
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Conditions of chronic stress are associated with genetic instability in many organisms, but the roles of stress responses in mutagenesis have so far been elucidated only in bacteria. Here, we present data demonstrating that the environmental stress response (ESR) in yeast functions in mutagenesis induced by proteotoxic stress. We show that the drug canavanine causes proteotoxic stress, activate...
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Aerobic organisms are constantly exposed to reactive oxygen species (ROS), generated as normal metabolism byproducts, especially by respiration [1,2]. To modulate ROS concentrations and to counteract their deleterious effects, there are several antioxidant systems with an apparent functional redundancy, which may provide an evolutionary advantage. Saccharomyces cerevisiae cells possess multiple...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2020
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.2005648117